Abstract
Background: We report the design, synthesis and evaluation of a series of 4-biaryl substituted 2-amino benzo[h]chromene derivatives as potential cytotoxic agents.
Methods: The one-pot synthesis of this class of compounds was carried out under ultrasound irradiation using an MCR involving Pd/C-catalyzed Suzuki-Miyaura coupling as a key step.
Result and Conclusion: Several of these compounds showed promising cytotoxicities when tested against cancer cell lines but no or little effects on non-cancerous cell lines.
Keywords: 2-amino benzo[h]chromene, MCR, Pd/C, cytotoxicity, cytotoxic agents, potential treatment.
Letters in Drug Design & Discovery
Title:Pd/C-catalyzed Synthesis of 4-biaryl Substituted 2-amino benzo[h] chromene Derivatives as Potential Cytotoxic Agents
Volume: 15 Issue: 2
Author(s): Chekuri Sharmila Rani, Meda Haritha, Mandava V. Basaveswara Rao*Manojit Pal*
Affiliation:
- Department of Chemistry, Krishna University, Machilipatnam-521001, Andhra Pradesh,India
- Dr. Reddy's Institute of Life Sciences, University of Hyderabad Campus, Hyderabad 500046,India
Keywords: 2-amino benzo[h]chromene, MCR, Pd/C, cytotoxicity, cytotoxic agents, potential treatment.
Abstract: Background: We report the design, synthesis and evaluation of a series of 4-biaryl substituted 2-amino benzo[h]chromene derivatives as potential cytotoxic agents.
Methods: The one-pot synthesis of this class of compounds was carried out under ultrasound irradiation using an MCR involving Pd/C-catalyzed Suzuki-Miyaura coupling as a key step.
Result and Conclusion: Several of these compounds showed promising cytotoxicities when tested against cancer cell lines but no or little effects on non-cancerous cell lines.
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Cite this article as:
Rani Sharmila Chekuri , Haritha Meda, Basaveswara Rao V. Mandava *, Pal Manojit*, Pd/C-catalyzed Synthesis of 4-biaryl Substituted 2-amino benzo[h] chromene Derivatives as Potential Cytotoxic Agents, Letters in Drug Design & Discovery 2018; 15 (2) . https://dx.doi.org/10.2174/1570180814666170530094023
DOI https://dx.doi.org/10.2174/1570180814666170530094023 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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