Pd/C-catalyzed Synthesis of 4-biaryl Substituted 2-amino benzo[h] chromene Derivatives as Potential Cytotoxic Agents

Author(s): Chekuri Sharmila Rani, Meda Haritha, Mandava V. Basaveswara Rao*, Manojit Pal*.

Journal Name: Letters in Drug Design & Discovery

Volume 15 , Issue 2 , 2018

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Abstract:

Background: We report the design, synthesis and evaluation of a series of 4-biaryl substituted 2-amino benzo[h]chromene derivatives as potential cytotoxic agents.

Methods: The one-pot synthesis of this class of compounds was carried out under ultrasound irradiation using an MCR involving Pd/C-catalyzed Suzuki-Miyaura coupling as a key step.

Result and Conclusion: Several of these compounds showed promising cytotoxicities when tested against cancer cell lines but no or little effects on non-cancerous cell lines.

Keywords: 2-amino benzo[h]chromene, MCR, Pd/C, cytotoxicity, cytotoxic agents, potential treatment.

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Article Details

VOLUME: 15
ISSUE: 2
Year: 2018
Page: [160 - 168]
Pages: 9
DOI: 10.2174/1570180814666170530094023
Price: $58

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