Abstract
1,4-benzothiazine (1,4-B), a pharmacophore of anti-psychotic drug phenothiazines, is a vital class of heterocyclic compounds implicating versatile biological activities.
The aim of this review article is to summarize various synthetic strategies, biological activities and structure activity relationship concerning the bioactive heterocycle, 1,4-B.
Synthetic chemists have discovered numerous routes for the syntheses of various 1,4-B analogues that show excellent activities through multiple mechanisms. The direct comparison of activities with the parent 1,4-B derivatives enables a systematic analysis of the structure activity relationship (SAR) among the series. This review article is an effort to compile the progress in the chemistry, biological activity and SAR of 1,4-benzothiazine in a systematic way.
The previously explored insights included in this article collectively suggests that 1,4-benzothiazines (1,4-Bs), besides offering several interesting biological activities, have a tremendous ability to regulate various types of cancer.
The previous work on the present nucleus summarized in this article will help the researchers to design their work based on 1,4-benzothiazine ring.
Keywords: 1, 4-Benzoheterozines, mechanism of reaction, synthetic strategies, X-ray crystal structure, biological activities, structure activity relationship.
Mini-Reviews in Medicinal Chemistry
Title:1,4-Benzothiazines-A Biologically Attractive Scaffold
Volume: 18 Issue: 1
Author(s): Amit Rai, Ashok K. Singh, Vinit Raj and Sudipta Saha*
Affiliation:
- Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow-226025,India
Keywords: 1, 4-Benzoheterozines, mechanism of reaction, synthetic strategies, X-ray crystal structure, biological activities, structure activity relationship.
Abstract: 1,4-benzothiazine (1,4-B), a pharmacophore of anti-psychotic drug phenothiazines, is a vital class of heterocyclic compounds implicating versatile biological activities.
The aim of this review article is to summarize various synthetic strategies, biological activities and structure activity relationship concerning the bioactive heterocycle, 1,4-B.
Synthetic chemists have discovered numerous routes for the syntheses of various 1,4-B analogues that show excellent activities through multiple mechanisms. The direct comparison of activities with the parent 1,4-B derivatives enables a systematic analysis of the structure activity relationship (SAR) among the series. This review article is an effort to compile the progress in the chemistry, biological activity and SAR of 1,4-benzothiazine in a systematic way.
The previously explored insights included in this article collectively suggests that 1,4-benzothiazines (1,4-Bs), besides offering several interesting biological activities, have a tremendous ability to regulate various types of cancer.
The previous work on the present nucleus summarized in this article will help the researchers to design their work based on 1,4-benzothiazine ring.
Export Options
About this article
Cite this article as:
Rai Amit , Singh K. Ashok , Raj Vinit and Saha Sudipta *, 1,4-Benzothiazines-A Biologically Attractive Scaffold, Mini-Reviews in Medicinal Chemistry 2018; 18 (1) . https://dx.doi.org/10.2174/1389557517666170529075556
DOI https://dx.doi.org/10.2174/1389557517666170529075556 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
Natural Products in Drug Discovery
Natural products have always been one of the important ways of drug discovery due to their novel skeleton and diverse functional group characteristics. According to statistics, between 1981 and 2019, the FDA approved a total of 1,394 small molecule drugs for marketing, of which 930 marketed drugs originated from the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Evaluation of Pregabalin Therapy in Peripheral Neuropathy
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Maslinic Acid Inhibits Cervical Intraepithelial Neoplasia by Suppressing Interleukin- 6 and Enhancing Apoptosis in a Mouse Model
Anti-Cancer Agents in Medicinal Chemistry Synthesis of 3-(2, 8, 9-trioxa-5-aza-1-germatricyclo [3.3.3.0] Undecane-1- yl)-3-(4-hydroxyl-3-methoxyphenyl)-propionic Acid and its Inhibitory Effect on the Cervical Tumor U14 in vitro and in vivo
Medicinal Chemistry Oncogene Expression Modulation in Cancer Cell Lines by DNA G-Quadruplex-Interactive Small Molecules
Current Medicinal Chemistry Current Treatment for Cervical Cancer: An Update
Anti-Cancer Agents in Medicinal Chemistry Relationship Between Polymerase Gamma (POLG) Polymorphisms and Antiretroviral Therapy-Induced Lipodystrophy in HIV-1 Infected Patients: A Case-Control Study
Current HIV Research Analysis of miRNAs Targeting 3’UTR of H2AFX Gene: a General <i>in Silico</i> Approach
MicroRNA Impact of COVID-19 on Gender Equality, Sexual and Reproductive Health Rights of Adolescent Girls and Young Women: A Narrative Review
Current Women`s Health Reviews Comparative Proteomics and Bioinformatics Analysis of Tissue from Non-Small Cell Lung Cancer Patients
Current Proteomics Implication of Circadian Rhythms and Melatonin in Major Depressive Disorder: The Evidence Base for New Antidepressant Treatment
Current Psychiatry Reviews Chemical Constituents and Bioactivities of the Plants of Genus Flemingia Roxb. et Ait. (Leguminosae)
Combinatorial Chemistry & High Throughput Screening Pharmacological Characteristics of Parenteral IGF-I Administration
Current Pharmaceutical Biotechnology The Human Desmin Promoter Drives Robust Gene Expression for Skeletal Muscle Stem Cell-Mediated Gene Therapy
Current Gene Therapy Roles of miRNA in the Initiation and Development of Colorectal Carcinoma
Current Pharmaceutical Design A Novel Class of Emerging Anticancer Compounds: Oxyprenylated Secondary Metabolites from Plants and Fungi
Current Medicinal Chemistry Cutting the Limits of Aminobisphosphonates: New Strategies for the Potentiation of their Anti-Tumour Effects
Current Cancer Drug Targets Carcinoma of the Lower Uterine Segment (LUS): Clinicopathological Characteristics and Association with Lynch Syndrome
Current Genomics Nanopotentiation of Propolis for Revocation of Enzyme Imbalance in UVB Induced Cutaneous Toxicity in Murine Model: a Preliminary Study for Chemoprotection of Skin Cancer
Drug Delivery Letters Identification of Novel Key Targets and Candidate Drugs in Oral Squamous Cell Carcinoma
Current Bioinformatics Carbohydrates: Potential Sweet Tools Against Cancer
Current Medicinal Chemistry