Hyaluronate-Lipid Nanohybrids: Fruitful Harmony in Cancer Targeting

Author(s): May S. Freag*.

Journal Name: Current Pharmaceutical Design

Volume 23 , Issue 35 , 2017

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Abstract:

Significant research efforts have been concerned over the past few years to design carrier systems that could specifically deliver active agents to the tumor sites, with the purposes of maximizing the therapeutic benefits and minimizing the toxic side-effects. Hyaluronic acid is a type of polysaccharide that has been extensively studied as a selective targeting ligand to cancerous cells that overexpress its specific receptor CD44. The aim of this review is to highlight the role of HA in cancer, focusing on the recent advances of HA-functionalized lipid nanoparticles towards cancer therapy and imaging.

Keywords: Cancer targeting, CD44 receptors, Hyaluronic acid, Lipid nanoparticles, tumor, polysaccharide.

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Article Details

VOLUME: 23
ISSUE: 35
Year: 2017
Page: [5283 - 5291]
Pages: 9
DOI: 10.2174/1381612823666170526103015
Price: $58

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