Significant research efforts have been concerned over the past few years to design carrier systems that
could specifically deliver active agents to the tumor sites, with the purposes of maximizing the therapeutic benefits
and minimizing the toxic side-effects. Hyaluronic acid is a type of polysaccharide that has been extensively
studied as a selective targeting ligand to cancerous cells that overexpress its specific receptor CD44. The aim of
this review is to highlight the role of HA in cancer, focusing on the recent advances of HA-functionalized lipid
nanoparticles towards cancer therapy and imaging.
Keywords: Cancer targeting, CD44 receptors, Hyaluronic acid, Lipid nanoparticles, tumor, polysaccharide.
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