Targeting DNA Minor Groove by Hybrid Molecules as Anticancer Agents

Author(s): Shalini Nekkanti , Ramya Tokala, Nagula Shankaraiah *.

Journal Name: Current Medicinal Chemistry

Volume 24 , Issue 26 , 2017

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Abstract:

Agents which can recognize and bind specific sequences of DNA offer selective therapy through the modulation of specific transcription factors or genes. Recently, there has been renewed interest in the field of anticancer minor groove binders. This may be attributed to the fact that many compounds of this class have demonstrated significant antitumor activity against a wide variety of cancers in recent clinical trials. This review will discuss the recent efforts to overcome the drawbacks of existing minor groove binding anticancer agents through rational drug design based on scaffolds with known antitumor activity.

Keywords: Anticancer, distamycin derivatives, DNA minor groove, pyrrolo[2, 1-c][1, 4]benzodiazepines, small molecules, β-carboline.

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Article Details

VOLUME: 24
ISSUE: 26
Year: 2017
Page: [2887 - 2907]
Pages: 21
DOI: 10.2174/0929867324666170523102730
Price: $58

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