Background: Dissipative particle dynamics (DPD) is a simulation method that has one of
its applications in the field of pharmaceutical science and drug delivery.
Objective: DPD is employed to study morphology and some other characteristics of polymeric nanomicelles.
Two systems were considered in this study: system A which includes curcumin, Polycaprolactone
(PCL), Polyethylene glycol (PEG) and water beads and system B which includes paclitaxel,
Polylactic acid (PLA), PEG and water beads.
Method: In this study we focused on the simulation of drug entrapment in polymeric micelles using
Results: Results indicated that the qualitative comparison of polymeric-micelles with different compositions,
after carefully tuning input parameters and simulation conditions, can be successfully performed
Conclusion: Considering real state of a system for DPD simulation will have a great impact on the reliability
of the simulation results.