Synthesis of New Antibacterial Cubane-based Nanocomposite and its Application in Combination Cancer Therapy

Author(s): Elham Zakerzadeh, Roya Salehi*, Mehrdad Mahkam*.

Journal Name: Anti-Cancer Agents in Medicinal Chemistry

Volume 17 , Issue 14 , 2017

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Abstract:

Background: The need for therapeutically effective anticancer drug delivery systems constantly persuades researchers to explore novel strategies.

Objective: In this study a novel cubane based antibacterial nanocomposite was tailored as dual chemotherapy drug delivery vesicle in order to increase the therapeutic outcome in cancer therapy.

Method: The physico-chemical characterization of engineered nanocarrier was assessed by Fourier transforms infrared spectroscopy (FTIR), Hydrogen nuclear magnetic resonance spectroscopy (1H NMR), Thermogravimetric analysis (TGA), and Field emission scanning electron microscopy-energy dispersive using X-ray (FESEMEDX). The antibacterial activity of novel developed nanocomposite was tested by determining minimum inhibitory concentration (MIC) values against Pseudomonas aeruginosa, Escherichia Coli and Candida albicans.

Results: In order to investigate the efficacy of novel engineered nanocomposite (with average particle size of 50 nm) as dual anticancer drug delivery, DOX and MTX were bind to nanocarrier with encapsulation efficiency and loading content of around 97.3 ± 2.7% and 20.8 ± 1.6 %, respectively. Dual drugs released simultaneously with distinct tumor targeted, pH responsive sustained release manner. Moreover, the probable antitumoral activity of this engineered nanocomposite system against MCF7 cell lines was evaluated by MTT assay and cell cycle studies. The outcomes showed that novel engineered nanocomposite had no cytotoxic effects, while DOX@MTX-loaded nanocomposite possessed higher growth inhibition property and higher S-phase arrest as compared to cells treated with DOX@MTX alone.

Conclusion: It was concluded that this novel cubane based drug delivery vehicle could process antibacterial and anticancer therapeutics spontaneously, representing promising tumor targeted system in nanomedicine.

Keywords: Cubane, antibacterial polymers, dual anticancer drug, combination therapy, multidrug resistance, pH-sensitive nanocomposite.

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Article Details

VOLUME: 17
ISSUE: 14
Year: 2017
Page: [1898 - 1914]
Pages: 17
DOI: 10.2174/1871520617666170522124711
Price: $58

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