The DNA binding protein and chromatin structural regulator DEK regulate many cellular
processes. These include proliferation, differentiation, apoptosis, senescence, DNA repairing and the
maintenance of stem cell phenotype. DEK is increasingly recognized as a crucial player in many
steps of cancer initiation and progression, and is precisely regulated by abundant promoting and inhibiting
factors directly or indirectly. DEK may serve as an architectural modulating protein to regulate
the expression and function of multiple human genes in cancer cells. In this article we have reviewed
the specificities and complexities of DEK in the regulation of transcription factors and global
chromatin, including its biologic roles in malignant cells, and summarized the current research. The
possible use of DEK as a diagnostic marker and drug target in the prevention or treatment of tumors
is also discussed.
Keywords: DEK, cancer, gene regulations, biologic roles, diagnostic marker, drug target.
Rights & PermissionsPrintExport