Anthocyanins: Multi-Target Agents for Prevention and Therapy of Chronic Diseases

Author(s): Swathi Putta, Nagendra S. Yarla*, Ilaria Peluso, Dinesh K. Tiwari, Gorla V. Reddy, Priyanka V. Giri, Naresh Kumar, Ramarao Malla, Vijaya Rachel, P. Veera Bramhachari, Rama S. Reddy D, Ramesh Bade, Mastan Mannarapu, George E. Barreto, Da-Yong Lu, Vadim V. Tarasov, Vladimir N. Chubarev, Frederico F. Ribeiro, Luciana Scotti*, Marcus T. Scotti, M.A. Kamal, Ghulam Md Ashraf, Gjumrakch Aliev, George Perry, Satyajit D. Sarker, Chinthalapally V. Rao, Anupam Bishayee.

Journal Name: Current Pharmaceutical Design

Volume 23 , Issue 41 , 2017

Abstract:

Anthocyanins, a flavonoid class of polyphenols, are water soluble dark colored natural pigments found in fruits and vegetables. Owing to their wide distribution in plant materials, dietary consumption of anthocyanins is high compared to other flavonoids. Anthocyanins, due to their multifaceted medicinal properties are the active components in many herbal folk medicines. As in vitro and in vivo results, animal models, and clinical trials in various cell lines suggest, anthocyanins possess antioxidant, antidiabetic, antihyperlipidemic, anti-inflammatory, anticarcinogenic, antiulcer, and preventive activities against cardiovascular diseases. Additionally, anthocyanins exhibit chemotherapeutic, cardioprotective, hepatoprotective, and neuroprotective activities. In the diet, anthocyanins are absorbed in the stomach and intestinal cells and rapidly detected in the plasma. These promising properties of anthocyanins may well provide health benefits against chronic diseases.

Keywords: Anthocyanins, multitarget therapeutic agents, antioxidant, antidiabetic, antihyperlipidemic, anti-inflammatory and anticarcinogenic activity.

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Article Details

VOLUME: 23
ISSUE: 41
Year: 2017
Page: [6321 - 6346]
Pages: 26
DOI: 10.2174/1381612823666170519151801
Price: $58

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