In the last decades, gene therapy has become a novel therapeutic strategy for cancer treatment, including
immunologic and molecular approaches. Among molecular avenue, the design of efficient and effective gene
delivery systems, like cationic liposomes and niosomes, has been widely investigated and proposed as the most
promising research area. The advantages of cationic vesicles rely on their natural ability to form complexes with
anionic genetic molecules and deliver them into the cells via the endosomal pathway. Obviously, cationic vesicles-
mediated gene delivery is affected by numerous factors, in particular composition, that strongly affects vesicle
physical-chemistry characteristics and transfection effectiveness. This review will analyse the potential of
cationic nanocarriers in cancer gene therapy, focusing on the role of liposomes and niosomes as vesicular devices
and giving an exhaustive collection of the most representative investigations.
Keywords: Liposomes, niosomes, gene therapy, cancer, liposomes, cationic nanocarriers.
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