Title:Recent Advances in Synthesis of Functionalized β-Lactams through Cyclization of N-Propargyl Amine/Amide Derivatives
VOLUME: 22 ISSUE: 2
Author(s):Esmail Vessally*, Mirzaagha Babazadeh, Akram Hosseinian, Ladan Edjlali* and Lakshmaiah Sreerama*
Affiliation:Department of Chemistry, Payame Noor University, Tehran, Department of Chemistry, Tabriz Branch, Islamic Azad University, Tabriz, Department of Engineering Science, College of Engineering, University of Tehran, P.O. Box 11365-4563, Tehran, Department of Chemistry, Tabriz Branch, Islamic Azad University, Tabriz, Department of Chemistry and Earth Sciences, College of Arts and Science, Qatar University, P.O. Box 2713, Doha
Keywords:β-lactams, N-propargylamines, N-propargylamides, 4-exo-dig cyclization, Ugi-adducts, carbon monoxide.
Abstract:β-lactams have attracted a significant attention due to their potential biological
activities and wide variety of synthetic applications. Developing novel and efficient
methods for construction of functionalized β-lactams has been the subject of a number of
papers in recent years. N-Propargyl amines/amides are one of the most specific class of
alkynes having diverse reaction patterns. It is well known that they can undergo a number
of cyclization reactions to produce various significant nitrogen containing heterocycles.
This review surveys literature methods for the synthesis of highly substituted β-lactams
from simple and easily available N-propargyl amine/amide derivatives from 1991 to 2017.
