N-(2-(Arylmethylimino)Ethyl)-7-Chloroquinolin-4-Amine Derivatives: A New and Potent Class of Anticancer Agents

Author(s): Ligia S. da Silveira Pinto, Marcus V.N. de Souza*, Carlos R. Kaiser, James L. Wardell, Solange M.S.V. Wardell.

Journal Name: Letters in Drug Design & Discovery

Volume 15 , Issue 2 , 2018

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Abstract:

Background: In this study, we reported the in vitro cytotoxicity activities of a series of N-(2-(arylmethylimino)ethyl)-7-chloroquinolin-4-amine derivatives against four human cancer cell lines.

Methods: Good activities were obtained for compounds having aryl groups = 2-hydroxyphenyl, pyridinyl, 5-nitrofuran-2-yl and 5-nitrothiophen-2-yl.

Results and Conclusion: The results indicate that this group of compounds is a good starting point for the potential discovery of new prototypes against cancer.

Keywords: Cancer, cytotoxicity activity, quinoline derivatives, drugs, in vitro, cell lines.

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Article Details

VOLUME: 15
ISSUE: 2
Year: 2018
Page: [113 - 117]
Pages: 5
DOI: 10.2174/1570180814666170512123720
Price: $58

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