Moulding, Extrusion, Floss and Three Dimensional Printing Technologies for Developing Fast Dissolving/Disintegrating Tablets
Pp. 99-118 (20)
Vikas A. Saharan
This chapter describes various developments in the designing, fabrication
and manufacturing of FDTs using various technologies based on moulding, extrusion,
floss, and three dimensional printing (3DP). Moulding has evolved from conventional
moulding/tablet triturates to heat moulding, moulding methods involving use of
compressed gases or low boiling point solvents, microwave drying, vacuum drying and
compression of wet granules in especially designed moulding machine. Extrusion is not
yet fully explored for developing FDTs. Floss techniques has moved ahead from
Shearform® floss through liquiflash to creation of microparticulates. Rapid prototyping
techniques, especially three dimensional printing (3DP), have enabled the use of
computer aided designing (CAD) possibilities in manufacturing of highly porous
dosage form offering immediate and complex drug release characteristics, tablets of
any shape and dosage forms which can flash into a matter of seconds.
3DPTM, Compaction, Compression, Computer aided design, Cotton
candy, EMP®, FlashDose®, Floss, Formulation, Free form fabrication, Heat
moulding, Microwave drying, Press through package, Rapid prototyping,
Shearform®, Tablet, TheriFlash®, TheriForm®, Vacuum drying, Wet compression.
Department of Pharmaceutics, School of Pharmaceutical Sciences, Sardar Bhagwan Singh Post Graduate Institute of Biomedical Sciences and Research (www.sbspgi.edu.in), Balawala, Dehradun 248161, Uttarakhand, India.