HLA-C Single Nucleotide Polymorphism Associated with Increased Viral Load Level in HIV-1 Infected Individuals from Northeast Brazil

Author(s): Ronaldo Celerino da Silva, Ronald Rodrigues Moura, Antonio Victor Campos Coelho, Luiz Cláudio Arraes, Lucas André Cavalcanti Brandão, Sergio Crovella, Rafael Lima Guimarães*.

Journal Name: Current HIV Research

Volume 15 , Issue 4 , 2017

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Abstract:

Background: Genetic variations in Human leukocyte antigen C (HLA-C), Zinc ribbon domain containing 1 (ZNRD1) and its antisense RNA (ZNRD1-AS1) genes are known to influence the HIV-1 replication and disease progression.

Objective and Method: We evaluated the distribution of HLA-C (rs10484554, rs9264942) and ZNRD1 (rs8321) and ZNRD1-AS1 (rs3869068), single nucleotide polymorphisms (SNPs) in 266 HIV-1-infected and 223 unexposed-uninfected individuals from Northeast Brazil and their relation to HIV-1 infection, CD4 T cells count and viral load pre-treatment.

Results: HLA-C SNPs were in Linkage Disequilibrium (D’=0.84), constituting four possible haplotypes. Our results showed that HLA-C, ZNRD1 and ZNRD1-AS1 SNPs as well as HLA-C haplotypes frequencies were not significantly different between HIV-1-infected and unexposed-uninfected individuals. In addition, we analyzed HLA-C and ZNRD-1 and ZNRD1-AS1 SNPs considering CD4+ T cell counts and viral load before the antiretroviral treatment. Individuals carrying HLA-C rs9264942 TT genotype showed a significant increased level of HIV-1 viral load pre-treatment, in comparison with individuals carrying the CC genotype (p-value = 0.0092). Finally, we stratified our findings according to CCR5Δ32 allele presence along with the studied SNPs: no statistically significant influence over viral load pre-treatment has been found.

Conclusion: The association between HLA-C rs9264942 SNP and viral load prior treatment in an admixed population from North East Brazil was in agreement with findings from previous studies obtained on different ethnic groups; however more studies should be conducted in order to clarify how HLA-C impair the HIV-1 replication

Keywords: HLA-C, ZNRD1, ZNRD1-AS1, SNPs, HIV-1 infection, viral load.

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Article Details

VOLUME: 15
ISSUE: 4
Year: 2017
Page: [266 - 272]
Pages: 7
DOI: 10.2174/1570162X15666170511141741
Price: $58

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