Current Gene Therapy

Ignacio Anegon
Director INSERM UMR 1064-Center for Research in Transplantation and Immunology
CHU de Nantes. 30, boulevard
Nantes
France

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Smart Micro/Nano-robotic Systems for Gene Delivery

Author(s): Alireza Pedram, Hossein Nejat Pishkenari.

Abstract:

Background: Small scale robotics have attracted growing attention for the prospect of targeting and accessing cell-sized sites, necessary for high precision biomedical applications and drug/gene delivery. The loss of controlled gene therapy, inducing systemic side effects and reduced therapeutic efficiency, can be settled utilizing these intelligent carriers.

Methods: Newly proposed solutions for the main challenges of control, power supplying, gene release and final carrier extraction/degradation have shifted these smart miniature robots to the point of being employed for practical applications of transferring oligonucleotides (pDNA, siRNA, mRNA, etc.) in near future.

Conclusion: In this paper, different scenarios and their endeavors to address the vital working demands and steps, in particular, carrier attachment and release, cell internalization, manipulation concerns as well as actuation systems are discussed.This review highlights some promising experimental results showing controlled gene release of robotic systems in comparison with current non-specific gene delivery methods.

Keywords: Gene delivery, Micro/nano-robotics, MRI actuation, Chemotaxis, Hybrid systems, Gene release.

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Article Details

VOLUME: 17
ISSUE: 2
Year: 2017
Page: [73 - 79]
Pages: 7
DOI: 10.2174/1566523217666170511111000
Price: $58