Natural Compounds: Cancer Preventive Agents
Pp. 64-86 (23)
Sandeep K Misra
Cancer chemoprevention is a rapidly evolving scientific research area.
Cancer chemoprevention is the application of natural or synthetic agents to reduce or
delay the onset of cancer. Different approaches are currently being used for cancer
prevention and one of these important approaches is the use of natural compounds.
Several natural compounds are currently under the investigation for their efficacy in
preventing cancer. These compounds include curcumin, tea polyphenols, resveratrol,
genistein, luteolin, lycopene among others. Curcumin is probably the most studied
natural molecule for its ability to prevent cancer. Many of these compounds are being
investigated using in vitro as well as animal models. Clinical trials are also underway
for many natural compounds to test their efficiency in cancer chemoprevention. Recent
evidence suggests that these natural molecules have antioxidant, anti-inflammatory,
immune-enhancing, cell cycle modifying and cell differentiating, apoptotic and
suppression of proliferation and angiogenesis properties. These natural compounds
target several molecular pathways. Some of these pathways include p53 family,
activator protein 1, NF-κB, growth factors among others.
Cancer chemoprevention, Molecular pathways, Natural compounds.
University of Mississippi, Oxford, Mississippi, USA 38677.