Pharmacokinetics of Botanical Drugs and Plant Extracts

(E-pub Ahead of Print)

Author(s): Gina Paola Domínguez Moré, Paola Andrea Cárdenas, Geison M. Costa, Cláudia M. O. Simões, Diana Marcela Aragón*.

Journal Name:Mini-Reviews in Medicinal Chemistry

Volume 17 , 2017

Abstract:

Botanical drugs contain plant extracts, which are complex mixtures of compounds. As with conventional drugs, it is necessary to validate their efficacy and safety through preclinical and clinical studies. However, pharmacokinetic studies for active constituents or characteristic markers in botanical drugs are rare. The objective of this review was to investigate the global state of the art in pharmacokinetic studies of active ingredients present in plant extracts and botanical drugs. A review of pharmacokinetics studies of chemical constituents of plant extracts and botanical drugs was performed, with a total of 135 studies published between January 2004 and February 2015 available in recognized scientific databases. Botanical preparations were mainly found in the form of aqueous extracts of roots and rhizomes. The most widely studied species was Salvia miltiorrhiza Bunge, and the compound most frequently used as a pharmacokinetic marker was berberine. Most studies were performed using the Sprague Dawley rat model, and the preparations were mainly administered orally in a single dose. Quantification of plasma concentrations of pharmacokinetic markers was performed mainly by liquid-liquid extraction, followed by high efficiency liquid chromatography coupled to mass spectrometry detector. In conclusion, in recent years there has been increasing interest among researchers worldwide in the study of the pharmacokinetics of bioactive compounds in botanical drugs and plant extracts, especially those from the Traditional Chinese Medicine.

Keywords: Pharmacokinetics, botanical drugs, plant extracts

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Article Details

VOLUME: 17
Year: 2017
(E-pub Ahead of Print)
DOI: 10.2174/1389557517666170510112508
Price: $95