5-HT3 Receptors: A Potential Therapeutic Target for Epilepsy

Author(s): Hongyan Zhao, Yang Lin*, Shurui Chen, Xin Li*, Hongliang Huo*.

Journal Name: Current Neuropharmacology

Volume 16 , Issue 1 , 2018

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Abstract:

Background: Epilepsy is a syndrome of brain dysfunction caused by spontaneous, abnormal discharge. Many anti-epileptic drugs have developed in past decades. 5-HT is an important neurotransmitter in the central and peripheral nervous system of the human body which is involved in a number of physiological activities, such as sensation, movement, and behavior. 5-HT subtype have been divided into seven sub-groups from 5-HT1 to 5HT7. However, the role of 5-HT3 receptor on epilepsy is unclear. Therefore, in this article, the possible role of 5-HT3 receptor on epilepsy was systemically reviewed.

Methods: Data were collected from Web of Science, Medline, Pubmed, Scopus, through searching of these keywords: “5-HT3” and “epilepsy”.

Results: An increasing number of studies have shown that the activation of the 5-HT3 receptor can inhibit epileptic seizures, while inhibition of the 5-HT3 receptor can promote spike waves.

Conclusion: In this review, we discuss the relationship between the 5HT3 receptor and epilepsy; this review may provide a new insight for clinical application of epilepsy treatment.

Keywords: 5-HT3 receptor, epilepsy, antagonists, Neuron, GABA, NMDA.

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Article Details

VOLUME: 16
ISSUE: 1
Year: 2018
Page: [29 - 36]
Pages: 8
DOI: 10.2174/1570159X15666170508170412

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