Background: Diabetes mellitus is the main reason of morbidity and mortality worldwide. In
recent years great attention has been paid to bioactivity of natural products due to their potential pharmacological
utilization. Echinochrome is a natural compound isolated from sea urchins and possesses
many biological effects. The hypoglycemic activity of echinochrome reported in many recent experiments.
Objective: In our study, we tried to collect all the possible hypoglycemic mechanism of echinochrome.
Conclusion: The hypoglycemic effect of echinochrome involving four main pathways; regeneration of
pancreas, decrease insulin resistant, increase insulin production and improve glucose homeostasis.
Keywords: Echinochrome, diabetes, acetylcholine, insulin resistance, oxidative stress, hypoglycemic mechanisms.
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