Abstract
Background: Diabetes mellitus is the main reason of morbidity and mortality worldwide. In recent years great attention has been paid to bioactivity of natural products due to their potential pharmacological utilization. Echinochrome is a natural compound isolated from sea urchins and possesses many biological effects. The hypoglycemic activity of echinochrome reported in many recent experiments.
Objective: In our study, we tried to collect all the possible hypoglycemic mechanism of echinochrome.
Conclusion: The hypoglycemic effect of echinochrome involving four main pathways; regeneration of pancreas, decrease insulin resistant, increase insulin production and improve glucose homeostasis.
Keywords: Echinochrome, diabetes, acetylcholine, insulin resistance, oxidative stress, hypoglycemic mechanisms.
Current Diabetes Reviews
Title:The Possible Hypoglycemic Mechanisms of Echinochrome
Volume: 14 Issue: 4
Author(s): Ayman Saber Mohamed*, Amel Mahmoud Soliman and Mohamed-Assem Said Marie
Affiliation:
- Zoology Department, Faculty of Science, Cairo University, 12613, Giza,Egypt
Keywords: Echinochrome, diabetes, acetylcholine, insulin resistance, oxidative stress, hypoglycemic mechanisms.
Abstract: Background: Diabetes mellitus is the main reason of morbidity and mortality worldwide. In recent years great attention has been paid to bioactivity of natural products due to their potential pharmacological utilization. Echinochrome is a natural compound isolated from sea urchins and possesses many biological effects. The hypoglycemic activity of echinochrome reported in many recent experiments.
Objective: In our study, we tried to collect all the possible hypoglycemic mechanism of echinochrome.
Conclusion: The hypoglycemic effect of echinochrome involving four main pathways; regeneration of pancreas, decrease insulin resistant, increase insulin production and improve glucose homeostasis.
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Cite this article as:
Mohamed Saber Ayman *, Soliman Mahmoud Amel and Marie Said Mohamed-Assem , The Possible Hypoglycemic Mechanisms of Echinochrome, Current Diabetes Reviews 2018; 14 (4) . https://dx.doi.org/10.2174/1573399813666170505120119
DOI https://dx.doi.org/10.2174/1573399813666170505120119 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
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