The Possible Hypoglycemic Mechanisms of Echinochrome

Author(s): Ayman Saber Mohamed*, Amel Mahmoud Soliman, Mohamed-Assem Said Marie.

Journal Name: Current Diabetes Reviews

Volume 14 , Issue 4 , 2018

Abstract:

Background: Diabetes mellitus is the main reason of morbidity and mortality worldwide. In recent years great attention has been paid to bioactivity of natural products due to their potential pharmacological utilization. Echinochrome is a natural compound isolated from sea urchins and possesses many biological effects. The hypoglycemic activity of echinochrome reported in many recent experiments.

Objective: In our study, we tried to collect all the possible hypoglycemic mechanism of echinochrome.

Conclusion: The hypoglycemic effect of echinochrome involving four main pathways; regeneration of pancreas, decrease insulin resistant, increase insulin production and improve glucose homeostasis.

Keywords: Echinochrome, diabetes, acetylcholine, insulin resistance, oxidative stress, hypoglycemic mechanisms.

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Article Details

VOLUME: 14
ISSUE: 4
Year: 2018
Page: [334 - 338]
Pages: 5
DOI: 10.2174/1573399813666170505120119
Price: $58

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