Background: Epilepsy is a chronic brain disease that is caused by various factors and
characterized by recurrent, episodic and temporary central nervous system dysfunction which
results due to excessive discharge of brain neurons. In the past decades, despite the continuous development
of antiepileptic drugs, there are still many patients with epilepsy progressing to drugresistant
epilepsy. Currently, surgical treatment is one of important way to cure drug-resistant
Methods: Data were collected from Web of Science, Medline, Pubmed, through searching of these
keywords: “surgery” and “drug-resistant epilepsy”.
Results: An increasing number of studies have shown that surgery plays an important role in the
treatment of drug-resistant epilepsy. Moreover, the comprehensive treatment mainly based on surgery
can achieve the remission and even cure of drug-resistant epilepsy.
Conclusion: In this review, we discuss the pathogenesis of drug-resistant epilepsy and the comprehensive
treatment mainly based on surgery; this review may provide a reference for the clinical
treatment of drug-resistant epilepsy.