Microbial Routes to (2R,3R)-2,3-Butanediol: Recent Advances and Future Prospects

Author(s): Neng-Zhong Xie*, Xian-Rui Chen, Qing-Yan Wang, Dong Chen, Qi-Shi Du, Guo-Ping Zhou*, Ri-Bo Huang*.

Journal Name: Current Topics in Medicinal Chemistry

Volume 17 , Issue 21 , 2017

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Abstract:

(2R,3R)-2,3-Butanediol has many industrial applications, such as it is used as an antifreeze agent and low freezing point fuel. In addition, it is particularly important to provide chiral groups in drugs. In recent years, this valuable bio-based chemical has attracted increasing attention, and significant progress has been made in the development of microbial cell factories for (2R,3R)-2,3-butanediol production. This article reviews recent advances and challenges in microbial routes to (2R,3R)-2,3- butanediol production, and highlights the metabolic engineering and synthetic biological approaches used to improve titers, yields, productivities, and optical purities. Finally, a systematic and integrative strategy for developing high-performance microbial cell factories is proposed.

Keywords: (2R, 3R)-2, 3-Butanediol, Microbial cell factory, Rational design, Metabolic engineering, Synthetic biology, Systematic and Integrative strategy.

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Article Details

VOLUME: 17
ISSUE: 21
Year: 2017
Page: [2433 - 2439]
Pages: 7
DOI: 10.2174/1568026617666170504101646
Price: $58

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