Addiction is a chronic, relapsing disease of the brain that includes drug-induced compulsive
seeking behavior and consumption of drugs. Dopamine (DA) is considered to be critical in drug
addiction due to reward mechanisms in the midbrain. In this article, we review the major animal
models in addictive drug experiments in vivo and in vitro. We discuss the relevance of the structure
and pharmacological function of DA receptors. To improve the understanding of the role of DA receptors
in reward pathways, specific brain regions, including the Ventral tegmental area, Nucleus accumbens,
Prefrontal cortex, and Habenula, are highlighted. These factors contribute to the development
of novel therapeutic targets that act at DA receptors. In addiction, the development of neuroimaging
method will increase our understanding of the mechanisms underlying drug addiction.
Keywords: Dopamine, Addiction, Dopamine receptors, Brain regions, Perforental cortex, PA receptor.
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