Purpose: To develop two PVC membrane sensors for determination of ciprofloxacin (CIP).
Method: Beta - or γ-cyclodextrin was investigated as electroactive material for the formation of sensor
1 and 2 in the presence of potassium tetrakis (4-chlorophenyl) borate (KTpClPB) as ion additive.
Results: The investigated sensors appeared fast, accurate, sensitive and showed near-Nernstian response
(50 mV/ decade) with a calibration range for CIP (1 ×10-3 - 8×10-6 and 1 × 10-3 - 1.0×10-5 mol L-1). The
detection limits were 9×10-6, and 8×10-6 mol L-1 for β- or γ- cyclodextrin sensor, respectively. The
measuring pH of the developed sensors was in 3 - 6 range. Selectivity coefficient of the proposed methods
indicates that both sensors showed a high selectivity for CIP in the presence of many ions and different
common drug excipients. The proposed mechanism is based on inclusion complex or host-guest
Conclusion: The advantages of the developed sensors are that it is accurate, selective, sensitive and cost
less compared with published instrumental methods of analysis. The proposed sensors have been utilized
for quantification of CIP in bulk and its formulation with good reproduicibilty compared with British