Directed Differentiation and Paracrine Mechanisms of Mesenchymal Stem Cells: Potential Implications for Tendon Repair and Regeneration

Title:Directed Differentiation and Paracrine Mechanisms of Mesenchymal Stem Cells: Potential Implications for Tendon Repair and Regeneration

Volume: 12 Issue: 6

Author(s): Bingyu Zhang, Qing Luo, Alexander Halim, Yang Ju, Yasuyuki Morita and Guanbin Song*

Affiliation:

• Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030,China

Keywords: Mesenchymal stem cells, directed differentiation, paracrine, tendon, injury, repair.

Abstract: Background: Tendon is composed of connective tissue, is able to retract with high tensile force, and plays a significant role in musculoskeletal motion. However, inappropriate physical training or accidents often result in tendon injuries. So far, the functional healing of injured tendon is still a great challenge in orthopedics. Mesenchymal stem cells (MSCs) are multilineage cells with the ability to self-renew and differentiate into a variety of cell types, including tenocytes. The plasticity of MSCs gives rise to the chance of improved healing of injured tendons and even tissue-engineered tendons. Recently, more and more works have shown that the paracrine mechanisms of MSCs also play a critical role in driving the tendon repair process.

Cite this article as:

Zhang Bingyu , Luo Qing, Halim Alexander , Ju Yang, Morita Yasuyuki and Song Guanbin *, Directed Differentiation and Paracrine Mechanisms of Mesenchymal Stem Cells: Potential Implications for Tendon Repair and Regeneration, Current Stem Cell Research & Therapy 2017; 12 (6) . https://dx.doi.org/10.2174/1574888X12666170502102423