Effect of the Organic Groups on the Performance of Hybrid Silica Based Materials used as Supports for Biomolecules

Author(s): Zoltan Dudas , Laszlo Almasy* .

Journal Name: Current Organic Chemistry

Volume 21 , Issue 27 , 2017

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Graphical Abstract:


Immobilization of biomolecules in porous supports, especially in silica matrices, is probably one of the most successful processes in biomaterials synthesis in the last three decades. The flexibility and versatility offered by the sol-gel process, ensured its leading position in the biomolecules immobilization. Functionalization with organic groups of the silica precursors leads to so-called organically modified silica gels. While there are many studies published recently about organically modified silica gels, the relationship between the functionalized support properties and the biomolecules activity is still poorly understood. The aim of this review is to summarize the available results on the influence of the organic functionalization of the silica support on the performance of immobilized biomolecules.

Keywords: sol-gel technique, organically modified silica, biomolecule encapsulation, catalysis, silica matrices, silica gels.

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Article Details

Year: 2017
Page: [2760 - 2767]
Pages: 8
DOI: 10.2174/1385272821666170428124946
Price: $58

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