Objective: Antioxidants protect the body against cellular damage. Saliva has
immunological, enzymatic and antioxidant defense systems. Uric acid is the main and
predominant salivary antioxidant. The aim of this study was to evaluate salivary uric acid
levels and pH in HIV-infected patients in the west of Iran.
Methods: HIV-infected patients were selected from behavioral advisory centers of
Hamadan and Kermanshah Provinces, west of Iran. Saliva was collected between 8
and10 in the morning. Five mL of whole unstimulated saliva was collected in 5 minutes
by spitting into sterilized Falcon tubes based on Navazesh method; pH was measured
with a pH meter and uric acid was assessed with spectrophotometric method. Data were
analyzed with STATA 12.
Results: Salivary pH in the HIV-positive group was lower (6.99±0.46) than the healthy
controls (7.14±1.03) but the difference was not statistically significant (P=380). Uric acid
concentrations in HIV-infected patients (2.94±2.14) were significantly lower in comparison
to the healthy controls (5.21±2.30). The results showed a statistically significant
decrease in the case group (P=0.001). Mean age and DMFT index of the case group
were higher than the control group.
Conclusion: Uric acid, the main antioxidant of saliva, was significantly lower in HIVinfected
individuals; pH also was lower in these patients. HIV can alter salivary antioxidant
status, which can influence patients' oral health status. Diet with antioxidant properties
might be helpful in these patients. More research is necessary to discover true antioxidant
and salivary changes and their relation with HIV consequences in future.