In recent years, fluorescent probes have recently attracted attention from researchers.
As a vital trace metal element, Cu2+ has an important role in the human body and
environment. Therefore, the development and design of Cu2+ small-molecular fluorescent
probes has been an active research area. This review focuses on the developments in the area
of small-molecular fluorescent probes for Cu2+ in biological applications according to different
sensing mechanisms including charge transfer (CT), electron transfer, energy transfer,
excited-state intramolecular proton transfer (ESIPT).
Keywords: Detection, Metal ions, Cu2+ small-molecular fluorescent probes, Biological applications, Sensing mechanisms,
charge transfer (CT).
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