Background: Acquired immunodeficiency syndrome or (AIDS) is a malady which is caused by
HIV (human immunodeficiency) virus and affects individuals on all continents. In the year 1987, the antiretroviral
therapy began improving the eminence of life for AIDS patients and increased the survival rates. Abacavir
is an antiretroviral drug approved by FDA in 1998, and is widely employed in the treatment of AIDS.
Objective: This review aims to examine gravely the various synthetic methodologies used for the synthesis of
abacavir. Carbocyclic nucleosides synthesis remains a dynamic field of research in medicinal area. Various
consistent and effective synthetic protocols for abacavir are accessible to researchers which affords the drug in
high yields as well as high regio- and stereoselectivity.
Conclusion: An effort has been carried out to provide an overview of the selected methods, main focus will be
on palladium catalyzed coupling and ring-closing metathesis. Resolution of intermediates involved in the synthesis
has also been tinted briefly.