Structure, Function, Involvement in Diseases and Targeting of 14-3-3 Proteins: An Update

Author(s): Ylenia Cau, Daniela Valensin, Mattia Mori, Sara Draghi, Maurizio Botta*.

Journal Name: Current Medicinal Chemistry

Volume 25 , Issue 1 , 2018

  Journal Home
Translate in Chinese
Submit Manuscript
Submit Proposal

Abstract:

14-3-3 is a class of proteins able to interact with a multitude of targets by establishing protein-protein interactions (PPIs). They are usually found in all eukaryotes with a conserved secondary structure and high sequence homology among species. 14-3-3 proteins are involved in many physiological and pathological cellular processes either by triggering or interfering with the activity of specific protein partners. In the last years, the scientific community has collected many evidences on the role played by seven human 14-3-3 isoforms in cancer or neurodegenerative diseases. Indeed, these proteins regulate the molecular mechanisms associated to these diseases by interacting with (i) oncogenic and (ii) pro-apoptotic proteins and (iii) with proteins involved in Parkinson and Alzheimer diseases. The discovery of small molecule modulators of 14-3-3 PPIs could facilitate complete understanding of the physiological role of these proteins, and might offer valuable therapeutic approaches for these critical pathological states.

Keywords: 14-3-3, cancer, neurodegeneration, protein-protein interaction, small molecules, drug discovery, phosphorylation.

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 25
ISSUE: 1
Year: 2018
Page: [5 - 21]
Pages: 17
DOI: 10.2174/0929867324666170426095015

Article Metrics

PDF: 111
HTML: 30
EPUB: 2
PRC: 1