Abstract
Background: Nutrition is important for the fetal developmental programming. Nutritional deficiency in early life could increase the susceptibility to many aging-related disorders including cognitive decline.
Objective: Our study aims to investigate the effect of early famine exposure on aging-associated cognitive function. Methods: We recruited 6790 subjects born between 1956 to 1964 during which the Great Chinese Famine occurred (1959-1961). Cognitive function of these subjects were evaluated using the Mini-Mental State Examination (MMSE), the Activities of Daily Living scale (ADL), the Instrumental Activities of Daily Living scale (IADL) and the Clinical Dementia Rating (CDR). Results: Our study identified that early exposure to the famine significantly increased the risk of cognitive impairments in later life, leading to higher prevalence of Mild Cognitive Impairment (MCI) and dementia. We also found the sex and rural-urban differences in this malnutrition-induced effect. Illiteracy, history of stroke or diabetes mellitus are great risk factors to facilitate the cognitive decline. Conclusion: These findings demonstrate that exposure to famine during early life including prenatal period and early childhood facilitates aging-associated cognitive deficits.Keywords: Famine, malnutrition, early life, risk factor, mild cognitive impairment, dementia.
Current Alzheimer Research
Title:Nutritional Deficiency in Early Life Facilitates Aging-Associated Cognitive Decline
Volume: 14 Issue: 8
Author(s): Yu Kang, Yun Zhang, Zijuan Feng, Mingjing Liu, Yanhua Li, Huan Yang, Dan Wang, Lingling Zheng, Dandan Lou, Liangping Cheng, Chunjiang Chen, Weitao Zhou, Yi Feng, Xiaoyong Li, Jianzhong Duan, Mengjiao Yu, Shou Yang, Yuhang Liu, Xin Wang, Bo Deng, Chenghui Liu, Xiuqing Yao, Chi Zhu, Chunrong Liang, Xiaolong Zeng, Sisi Ren, Qunying Li, Yin Zhong, Yong Zhang, Jun Kang, Yong Yan, Huaqing Meng, Zhaohui Zhong, Weihui Zhou, Yanjiang Wang, Tingyu Li*Weihong Song*
Affiliation:
- Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, and Ministry of Education Key Lab of Child Development and Disorders, Pediatric Research Institute, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children’s Hospital of Chongqing Medical University, Chongqing 400014,China
- Townsend Family Laboratories, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3,Canada
Keywords: Famine, malnutrition, early life, risk factor, mild cognitive impairment, dementia.
Abstract: Background: Nutrition is important for the fetal developmental programming. Nutritional deficiency in early life could increase the susceptibility to many aging-related disorders including cognitive decline.
Objective: Our study aims to investigate the effect of early famine exposure on aging-associated cognitive function. Methods: We recruited 6790 subjects born between 1956 to 1964 during which the Great Chinese Famine occurred (1959-1961). Cognitive function of these subjects were evaluated using the Mini-Mental State Examination (MMSE), the Activities of Daily Living scale (ADL), the Instrumental Activities of Daily Living scale (IADL) and the Clinical Dementia Rating (CDR). Results: Our study identified that early exposure to the famine significantly increased the risk of cognitive impairments in later life, leading to higher prevalence of Mild Cognitive Impairment (MCI) and dementia. We also found the sex and rural-urban differences in this malnutrition-induced effect. Illiteracy, history of stroke or diabetes mellitus are great risk factors to facilitate the cognitive decline. Conclusion: These findings demonstrate that exposure to famine during early life including prenatal period and early childhood facilitates aging-associated cognitive deficits.Export Options
About this article
Cite this article as:
Kang Yu, Zhang Yun, Feng Zijuan, Liu Mingjing, Li Yanhua, Yang Huan, Wang Dan, Zheng Lingling, Lou Dandan, Cheng Liangping, Chen Chunjiang, Zhou Weitao, Feng Yi, Li Xiaoyong, Duan Jianzhong , Yu Mengjiao, Yang Shou, Liu Yuhang, Wang Xin, Deng Bo, Liu Chenghui, Yao Xiuqing, Zhu Chi, Liang Chunrong , Zeng Xiaolong, Ren Sisi, Li Qunying, Zhong Yin, Zhang Yong, Kang Jun, Yan Yong, Meng Huaqing, Zhong Zhaohui, Zhou Weihui, Wang Yanjiang , Li Tingyu*, Song Weihong*, Nutritional Deficiency in Early Life Facilitates Aging-Associated Cognitive Decline, Current Alzheimer Research 2017; 14 (8) . https://dx.doi.org/10.2174/1567205014666170425112331
DOI https://dx.doi.org/10.2174/1567205014666170425112331 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Clinical Studies of Renal Nerve Ablation. Unanswered Questions for its Efficacy and Safety
Current Clinical Pharmacology Nature and Nurture in the Early-Life Origins of Metabolic Syndrome
Current Pharmaceutical Biotechnology Pharmacological Inhibition of Protein Tyrosine Phosphatase 1B: A Promising Strategy for the Treatment of Obesity and Type 2 Diabetes Mellitus
Current Medicinal Chemistry Relationship of Dietary Habits and Obesity to Oxidative Stress in Palauan People: Compared with Japanese and Mongolian People
Current Aging Science The Use of Sensory Nerve Stimulation and Compression Bandaging to Improve Sensory Nerve Function and Healing of Chronic Venous Leg Ulcers
Current Aging Science Curcumin, Hesperidin, and Rutin Selectively Interfere with Apoptosis Signaling and Attenuate Streptozotocin-Induced Oxidative Stress- Mediated Hyperglycemia
Current Neurovascular Research Topics on Pharmacology for Dietitians in Modern Practice
Current Nutrition & Food Science Nicotinamide Supplementation Protects Gestational Diabetic Rats by Reducing Oxidative Stress and Enhancing Immune Responses
Current Medicinal Chemistry Preface [Hot topic: Anti-Hypertensive Agents in Relation to Modifying Coronary Risk Factors (Executive Editor : Aurelio Leone)]
Current Pharmaceutical Design Role of Connexins and Pannexins in Ischemic Stroke
Current Medicinal Chemistry The Role of SHP-2 in Cell Signalling and Human Disease
Current Enzyme Inhibition Advances in the Topical Treatment of Diabetic Foot Ulcers
Current Diabetes Reviews Microcirculation Dysfunction: A Possible Mechanism Responsible for Reverse Redistribution in Myocardial Perfusion Imaging?
Current Medical Imaging Review of Vital Signs Monitoring Systems – Patient’s Acceptability, Issues and Challenges
Neuroscience and Biomedical Engineering (Discontinued) Celiac Disease: An Emerging Epidemic
Current Nutrition & Food Science Islet Amyloid Polypeptide and Diabetes
Current Protein & Peptide Science Silent Partner in Blood Vessel Homeostasis? Pervasive Role of Nitric Oxide in Vascular Disease
Current Hypertension Reviews Nanocrystals, a New Tool to Study Lipoprotein Metabolism and Atherosclerosis
Current Pharmaceutical Biotechnology Soluble Amyloid-β Levels and Late-Life Depression
Current Pharmaceutical Design Computational and Experimental Approaches to Design Inhibitors of Amylin Aggregation
Current Drug Targets