Abstract
Atherosclerosis is a chronic vascular disease in which atherosclerotic plaques develop in the arterial wall. It is believed that inflammation plays a major role in atherosclerotic formation and progression. Thus, atherosclerosis can be considered as an inflammatory disease of the arterial vessel. Mouse model demonstrated that T and B cell deficiency reduces the atherosclerotic burden in the formation of an atherosclerotic lesion. CD4+ T helper cells (Th), such as Th1 cells known being the major CD4+ T cell subtype found in mouse models of atherogenesis, increase plaque formation caused by oxLDL. IL-17 (also known as IL-17A) was produced by T cells or by a unique subset of T helper cells. IL-17-producing T cells express interferon- gamma (IFN-γ), an important regulator of immune function, which is highly expressed in atherosclerotic lesions, defying their neat characteristics as Th17 cells. Regulation of Th17 signal pathway may play a significant role in the pathogenesis of multiple inflammatory and autoimmune disorders, such as atherosclerosis. In this review, the structural features of IL-17 family and their roles involved in atherosclerosis are described.
Keywords: Atherosclerosis, plaques, mouse model, IL-17, lipoproteins, immune function, Th17 cells.
Current Medicinal Chemistry
Title:The Impact of IL-17 in Atherosclerosis
Volume: 24 Issue: 21
Author(s): Xinjie Lu*
Affiliation:
- The Mary and Garry Weston Molecular Immunology Laboratory, Thrombosis Research Institute, London, SW3 6LR,United Kingdom
Keywords: Atherosclerosis, plaques, mouse model, IL-17, lipoproteins, immune function, Th17 cells.
Abstract: Atherosclerosis is a chronic vascular disease in which atherosclerotic plaques develop in the arterial wall. It is believed that inflammation plays a major role in atherosclerotic formation and progression. Thus, atherosclerosis can be considered as an inflammatory disease of the arterial vessel. Mouse model demonstrated that T and B cell deficiency reduces the atherosclerotic burden in the formation of an atherosclerotic lesion. CD4+ T helper cells (Th), such as Th1 cells known being the major CD4+ T cell subtype found in mouse models of atherogenesis, increase plaque formation caused by oxLDL. IL-17 (also known as IL-17A) was produced by T cells or by a unique subset of T helper cells. IL-17-producing T cells express interferon- gamma (IFN-γ), an important regulator of immune function, which is highly expressed in atherosclerotic lesions, defying their neat characteristics as Th17 cells. Regulation of Th17 signal pathway may play a significant role in the pathogenesis of multiple inflammatory and autoimmune disorders, such as atherosclerosis. In this review, the structural features of IL-17 family and their roles involved in atherosclerosis are described.
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Cite this article as:
Lu Xinjie*, The Impact of IL-17 in Atherosclerosis, Current Medicinal Chemistry 2017; 24 (21) . https://dx.doi.org/10.2174/0929867324666170419150614
DOI https://dx.doi.org/10.2174/0929867324666170419150614 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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