Background: The Alzheimer’s Disease Assessment Scale-Cognitive subscale (ADASCog)
remains the most widely used test of longitudinal cognitive functioning in Alzheimer’s disease
(AD) clinical trials. Unlike most neuropsychological tests, the ADAS-Cog source documentation
worksheets are not uniform across clinical trials, and vary by document layout, inclusion of administration
and/or scoring instructions, and documentation of subtest scoring (e.g., recording correct versus
incorrect scores), among other differences. Many ADAS-Cog test administrators (raters) participate
in multiple AD trials and switching between different ADAS-Cog worksheets may increase the
likelihood of administration and/or scoring mistakes that lessen the reliability of the instrument. An
anonymous online survey sought raters’ experiences with ADAS-Cog worksheets and their opinions
on the design and content of the worksheets.
Results: Results of the survey indicated preference for structure and standardization of the ADASCog
worksheets, which has been considered in the development of a standard ADAS-Cog source
document by the Alzheimer’s Disease Cooperative Study (ADCS) Working Group.
Keywords: Alzheimer's Disease Assessment Scale (ADAS), Alzheimer’s disease, clinical trials, outcomes, rater, survey.
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