Current Drug Discovery Technologies

Vladimir P. Torchilin  
Department of Pharmaceutical Science Center
for Pharmaceutical Biotechnology and Nanomedicine
Northeastern University
Boston, MA 02115
USA

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Anti-Carcinogenic Effects of Carnosol-An Updated Review

(E-pub Ahead of Print)

Author(s): Saeed Samarghandian, Mohsen Azimi-Nezahad, Tahereh Farkhondeh.

Abstract:

Background: Despite the newly treatment procedures, cancer is considered as the main health threat nowadays and, therefore, new therapeutic options such as traditional medicine should be investigated. Rosemary (Rosmarinus officinalis L.) has been found to possess antitumor effects due to its major ingredients, including carnosic acid, carnosol, ursolic acid, and rosmarinic acid.

Objective: This study was designed to gather the recent literature findings from 2010 to 2016 on the cancer anti-tumor activities of carnosol and probably involved mechanisms.

Method: The online English papers were gathered through the various search websites, including PubMed, Iran Medex, Medline, Google Scholar, and Scopus from 2010 to 2016.

Results: Carnosol, the specific composition of rosemary, has been shown to have beneficial effects in keeping humans healthy and may be acted as an antitumor agent.

Conclusion: This review revealed that carnosol may be effective as an anti-tumor agent in the different types of cancer by inducing apoptosis and inhibiting the cell cycle division. However, more studies are needed to confirm carnosol therapeutic effects in human.

Keywords: carnosol, chemo-preventive, cancer

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Article Details

VOLUME: 14
Year: 2017
(E-pub Ahead of Print)
DOI: 10.2174/1570163814666170413121732
Price: $95