Ultrasound Assisted Synthesis of Quinoline Derivatives in the Presence of SnCl2·2H2O as a Precatalyst in Water: Evaluation of their Antibacterial Activities

Author(s): A.S.G. Prasad , T. Bhaskara Rao , D. Rambabu , Mandava V. Basaveswara Rao* , Manojit Pal* .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 18 , Issue 10 , 2018

Become EABM
Become Reviewer

Graphical Abstract:


Abstract:

Background: SnCl2·2H2O has been used as a convenient precatalyst for the one-pot and rapid synthesis of 2-substituted quinolines under ultrasound irradiation in water. The reaction involved a 3-component reaction of aniline, aldehydes, and ethyl 3,3-diethoxypropionate in the presence of aerial oxygen to give the desired products in good yields.

Conclusion: Several of these compounds showed antibacterial activities when tested against gram-positive and gram-negative species. One compound i.e. 4b showed promising activities across both the species.

Keywords: Antibacterial, MCRs, quinoline, ultrasound, water, SnCl2.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 18
ISSUE: 10
Year: 2018
Page: [895 - 903]
Pages: 9
DOI: 10.2174/1389557517666170412112619
Price: $58

Article Metrics

PDF: 25
HTML: 2
EPUB: 1
PRC: 1