Mini-Reviews in Medicinal Chemistry


Ultrasound Assisted Synthesis of Quinoline Derivatives in the Presence of SnCl2·2H2O as a Precatalyst in Water: Evaluation of their Antibacterial Activities

(E-pub Ahead of Print)

Author(s): A. S. G. Prasad, T. Bhaskara Rao, D. Rambabu, Mandava V. Basaveswara Rao, Manojit Pal.


SnCl2•2H2O has been used as a convenient precatalyst for the one-pot and rapid synthesis of 2-substituted quinolines under ultrasound irradiation in water. The reaction involved a 3-component reaction of aniline, aldehydes and ethyl 3,3-diethoxypropionate in the presence of aerial oxygen to give the desired products in good yields. Several of these compounds showed antibacterial activities when tested against gram-positive and gram-negative species. One compound i.e. 4b showed promising activities across both the species.

Keywords: Quinoline, Ultrasound, Water, SnCl2

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Article Details

Year: 2017
(E-pub Ahead of Print)
DOI: 10.2174/1389557517666170412112619
Price: $95