Background: Carbohydrates are of great interest for the synthesis of novel ribonucleosides
and C-Nucleosides which often show different pharmacological potential including antiinflammatory
and antineoplastic characteristics.
Introduction: In this research twelve aldopentose derivatives were examined and their chromatographic
properties were used to describe their pharmacokinetic profiles.
Methods: Thin layer chromatography was performed using three mobile phases: acetone–water (φ =
0.5–0.7 v/v), dioxane–water (φ = 0.5–0.7 v/v) and methanol–water (φ = 0.5–0.7 v/v). Multiple linear
regression was performed to examine correlation between lipophilicity and pharmacokinetic descriptors
of the examined molecules.
Results: Good oral absorption can be expected for all investigated compounds. Moderate volume of
distribution indicates low to moderate probability of their accumulation in body tissues. All investigated
molecules show good pharmacokinetic characteristics but compounds 2, 3, 5, 6 and 7 demonstrated the
best biological potential and biochemical activity such as inhibition of protease and kinase (compound
7) and possibility to be a ligand for GPCR.
Conclusion: Among the best candidates authors would emphasize structure 7 as the most promising
molecule regarding its pharmacological potential.