Background: In spite of the fact that advanced neuroimaging applications are used for
the evaluation of Tuberous Sclerosis (TS) patients, a few studies analyzed relationship between the
measurements of DTI (diffusion tensor imaging) and neurological findings.
Objectives: Evaluate DTI properties of cortical tubers and white matter lesions in TS, and analyze
whether there was a correlation between DTI findings and neurological findings.
Materials and Methods: MRI and DTI were performed on 31 subjects with TS. DTI findings of
subjects with TS were compared with those of the control group. Then, the correlation between
DTI values and neurological findings was analyzed.
Results: ADC values of cortical tubers and white matter lesions in subjects with epilepsy were
higher than in those without epilepsy. Additionally, the MRI lesion scores showed that our subjects
with epilepsy had more lesions than without epilepsy.
Conclusions: DTI findings of cortical tubers and white matter lesions in TS subjects could be related
to microstructural changes such as neuronal loss and the impairment of myelin integrity.
We hypothesized that severity neurological symptoms may be correlated with MRI lesion load and