Food Protein Induced Proctocolitis: A Benign Condition with an Obscure Immunologic Mechanism

Author(s): Sophia Tsabouri*, Nicolaos Nicolaou, Konstantinos Douros, Athina Papadopoulou, Kostas N. Priftis.

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets

Volume 17 , Issue 1 , 2017

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Graphical Abstract:


Food protein-induced proctocolitis (FPIP) is the most common colonic manifestation of food allergy in infants, accounting for up to 60% of exclusively breast-fed children. The causative foods derived from the mother’s diet, which are then excreted in her milk. The suggested risk factors for the development of FPIP are an immature immune system, altered intestinal permeability and other factors that activate local immune function, such as genetic susceptibility in combination with particularly sensitizing foods. FPIP is an enhanced immune responsiveness of some infants to very small amounts of food antigens, inducing an inflammatory mucosal response, mediated by T cells.

Keywords: Breast feeding, food allergy, infants, immunologic response, intolerance, allergic proctocolitis.

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Article Details

Year: 2017
Page: [32 - 37]
Pages: 6
DOI: 10.2174/1871530316666170331165356
Price: $58

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