Food protein-induced proctocolitis (FPIP) is the most common colonic manifestation of
food allergy in infants, accounting for up to 60% of exclusively breast-fed children. The causative
foods derived from the mother’s diet, which are then excreted in her milk. The suggested risk factors
for the development of FPIP are an immature immune system, altered intestinal permeability and
other factors that activate local immune function, such as genetic susceptibility in combination with
particularly sensitizing foods. FPIP is an enhanced immune responsiveness of some infants to very
small amounts of food antigens, inducing an inflammatory mucosal response, mediated by T cells.
Keywords: Breast feeding, food allergy, infants, immunologic response, intolerance, allergic proctocolitis.
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