Title:Hydroxypyridinone Derivatives: A Fascinating Class of Chelators with Therapeutic Applications - An Update
VOLUME: 25 ISSUE: 1
Author(s):Sílvia Chaves, Luca Piemontese, Asha Hiremathad and M. Amélia Santos*
Affiliation:Centro de Quimica Estrutural, Instituto Superior Tecnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa, Centro de Quimica Estrutural, Instituto Superior Tecnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa, Centro de Quimica Estrutural, Instituto Superior Tecnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa, Centro de Quimica Estrutural, Instituto Superior Tecnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa
Keywords:Hydroxypyridinones, 3-hydroxy-4-pyridinones, iron chelators, anti-neurodegeneratives, bioinorganic
medicinal chemistry.
Abstract:Hydroxypyridinones (HPs) are a family of N-heterocyclic metal chelators, which
have been an attractive target in the development of a variety of new pharmaceutical drugs,
due to their high metal chelating efficacy/specificity and easy derivatization to tune the desired
biological properties. In fact, along the last decades, hydroxypyridinone derivatives, but
mostly 3-hydroxy-4-pyridinone (3,4-HP), have been intensively used in drug design, following
either a multitarget approach, in which one chelating unity is extrafunctionalized (hybridized)
to enable the interaction with other important specific biological sites, or a polydenticity
approach, in which more than one chelating moiety is conveniently attached to one scaffold,
to increase the metal chelating efficacy. This review represents an update of the most recent
publications (2014-2016) in mono-HP hybrids, namely as potential anti-Alzheimer's drugs,
inhibitors of metalloenzymes and anti-microbials, and also polychelating compounds (poly-
HP), in view of potential application, such as anti-microbial/biostatic agents, luminescent biosensors
or diagnostic agents.
