Background: A series of new N-(2-benzoyl-4-chlorophenyl)-2-(4-(substituted phenyl)
piperazin-1-yl) acetamides (3a-j) have been synthesized by the chloroacetylation of 2-amino-5-
chlorbenzophenone which was further reacted with substituted phenylpiperazine.
Material: The chemical structures of the compounds were confirmed on the basis of their TLC, IR,
1HNMR, 13CNMR and by elemental analysis. The physicochemical similarity of the target compounds
with respect to standard drug diazepam was assessed by calculating from a set of physicochemical
properties using software programs.
Conclusion: Molecular docking studies revealed that the target compounds correctly dock into the
binding pocket of the GABAA receptor, while their bioavailability/drug-likeness was predicted to be
acceptable but requires future optimization. The anxiolytic and skeletal muscle relaxant activity of the
target compounds (3a-j) were evaluated in albino mice. Among them, compound 3h showed potent
anxiolytic and skeletal muscle relaxant activity.