Current Developments in Stroke

Current Developments in Stroke

Volume: 1

New Concepts in Stroke Diagnosis and Therapy

This volume presents a summary of recent research and debates on old and new aspects in stroke medicine. The volume covers topics such as causative factors of stroke such as hypertension, the immune ...
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Neuroregeneration after Stroke

Pp. -270 (299)

Marco Bacigaluppi, Gianluca Luigi Russo and Gianvito Martino

Abstract

Promoting tissue plasticity is a very important therapeutic approach to reduce post-stroke disability. The neurological damage occurring after stroke indeed is a consequence of disrupted brain connectivity circuits due to cellular degeneration and impairment of plasticity processes. Axonal degeneration is also invariably seen in remote brain structures that have neuroanatomical links to the ischemic area. Recovery from stroke is thus very much depending on the possibility to develop treatments able to halt the neurodegenerative process and to foster adaptive tissue plasticity. Due to the intricacy of the systems involved, therapies that foster endogenous repair processes in a spatially and time targeted manner are required. We here discuss the physiology of recovery processes occurring after stroke and the main strategies to foster compensatory neuronal networks aiming to reduce stroke-related disability.

Keywords:

Axonal sprouting, Critical period, Growth factors, Inflammation, Ischemic stroke, Neural stem cell, Plasticity, Transplantation.

Affiliation:

Neuroimmunology Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy.