Neuroregeneration after Stroke
Pp. -270 (299)
Marco Bacigaluppi, Gianluca Luigi Russo and Gianvito Martino
Promoting tissue plasticity is a very important therapeutic approach to
reduce post-stroke disability. The neurological damage occurring after stroke indeed is
a consequence of disrupted brain connectivity circuits due to cellular degeneration and
impairment of plasticity processes. Axonal degeneration is also invariably seen in
remote brain structures that have neuroanatomical links to the ischemic area. Recovery
from stroke is thus very much depending on the possibility to develop treatments able
to halt the neurodegenerative process and to foster adaptive tissue plasticity. Due to the
intricacy of the systems involved, therapies that foster endogenous repair processes in a
spatially and time targeted manner are required. We here discuss the physiology of
recovery processes occurring after stroke and the main strategies to foster
compensatory neuronal networks aiming to reduce stroke-related disability.
Axonal sprouting, Critical period, Growth factors, Inflammation,
Ischemic stroke, Neural stem cell, Plasticity, Transplantation.
Neuroimmunology Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy.