Current Developments in Stroke

Current Developments in Stroke

Volume: 1

New Concepts in Stroke Diagnosis and Therapy

This volume presents a summary of recent research and debates on old and new aspects in stroke medicine. The volume covers topics such as causative factors of stroke such as hypertension, the immune ...
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Pharmacological and Endovascular Recanalization Therapy

Pp. 250-269 (20)

E.C. Agostoni and M. Longoni

Abstract

The major aim of acute stroke treatment is to save the hypoperfused cerebral parenchyma in order to minimize residual disability. Early recanalization of occluded arteries with thrombolytic therapy is the most efficient procedure for protecting the brain parenchyma which is not yet infarcted.

Intravenous administration of Alteplase (recombinant tissue-type plasminogen activator – rtPA) has proven to be effective in reducing disability at 90 and 180 days after stroke in patients treated within 4.5 hours from symptoms onset.

Recently, striking results have been provided by the endovascular treatment, unless in a selected population. The use of the stent-retrievers or direct thrombus aspiration is now a good option for acute stroke treatment giving the opportunity of an effective multimodal therapeutic approach.

Keywords:

Actilyse, Acute therapy, Alteplase, Endovascular, Pharmacological, Recanalization, Stent retrievers, Stroke, Thrombectomy, Thrombolysis.

Affiliation:

Department of Neuroscience, Neurology and Stroke Unit of the ASST: “Grande Ospedale Metropolitano Niguarda”, Milan, Italy.