Current Developments in Stroke

Current Developments in Stroke

Volume: 1

New Concepts in Stroke Diagnosis and Therapy

This volume presents a summary of recent research and debates on old and new aspects in stroke medicine. The volume covers topics such as causative factors of stroke such as hypertension, the immune ...
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Intracerebral Bleeding and Oral Anticoagulant Therapies: Clinical Relevance and Management

Pp. 85-111 (27)

Monica Carpenedo

Abstract

Vitamin K antagonists such as warfarin and acenocumarol are the most widely used oral anticoagulants. Their clinical indications include both stroke prevention and prophylaxis and treatment of venous thromboembolism. Intracerebral hemorrhage (ICH) is the most important side effect of anticoagulant therapy accounting for almost 20% of all ICH. Non vitamin K anticoagulants or direct oral anticoagulants (DOACs) have been recently introduced in clinical practice due to their practical advantages over VKA. They are at least as effective as warfarin in the management of thromboembolic diseases and in the thromboprophylaxis of non-valvular atrial fibrillation, moreover, they have a more favorable safety profile. The present chapter will focus on vitamin K antagonists and DOACs mechanisms of action, on their pharmacokinetics and pharmacodynamics, and on the relative risk of bleeding during treatment.

Keywords:

Anticoagulation reversal, Anticoagulants, Bleeding risk, Intracerebral hemorrhage.

Affiliation:

Hematology and Transplant Unit, San Gerardo Hospital, Monza, Italy.