Background: Pancreatic cancer management remains a major challenge to society.
Poor prognosis results in dismal patient survival rates and quality of life post chemo/radiation
therapies. Although progress has been made in drug development for targeting pancreatic cancer,
accompanying issues of drug resistance renders it futile. While intake of fruits and vegetables
in routine diets has been linked to reduced risk of pancreatic cancer, a wide variety of natural
agents are being evaluated as adjuvant therapies in combination with frontline chemotherapeutics
in pancreatic cancer clinical trials.
Objective: This review highlights the emerging area of cancer chemoprevention with natural/
dietary compounds serving as novel agents possessing strong anticancer properties; these
are pleiotropic agents targeting multiple pathways with minimal toxicity in normal tissue.
Methods: We employed extensive literature search and considered all the relevant information
presented in a concise, well-balanced and structured format.
Results: Completed and ongoing human studies with natural agents have shown surprisingly
successful rates for regulating pancreatic carcinogenesis. Combinatorial therapies with synthetic,
approved drugs and natural agents not only improved the patient response rates, but also
helped in overcoming drug resistance and inducing chemosensitivity to the resistant tumors, as
opposed to monotherapies for pancreatic cancer chemoprevention.
Conclusion: The current review focuses on the available chemotherapeutic drugs and their
limitations, and moves on to discuss the wide realm of chemopreventive efficacy that the natural
agents have to offer. It discusses the underlying mechanisms of action and available information,
from extensive literature analysis, to highlight the novelty of these agents for their antitumor
effects against pancreatic cancer.