Near-infrared (NIR) light responsive nanomaterials have attracted considerable
attention due to their location in the biological window. Especially, lanthanide-doped
nanomaterials exhibit unique upconversion luminescence (UCL) properties with low
background interference and long luminescence lifetime, which makes them promising in
imaging diagnosis of cancers. Compared with traditional upconversion nanomaterials excited
by 980 nm laser, 808 nm excitation can overcome the disadvantages of high heating
effect and weak penetration depth induced by excitation source. Therefore, developing
808 nm excited upconversion nanoprobes will be important for the in vivo bio-imaging
and visualized theranostics of tumors in deep-tissue. In the review paper, we systematically
summarized the synthesis strategy and luminescence modulation of Nd3+-sensitized
upconversion nanomaterials under 808 nm excitation, discussed the influence of excitation
source on heating effect and penetration depth, and particularly focused on their applications
in UCL imaging, multi-modal imaging and imaging-guided therapy of cancers.
Keywords: Nd3+-sensitized upconversion nanomaterials, low-heating effect, strong penetration depth, upconversion
luminescence imaging, multi-modal imaging, visualized theranostics.
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