Frontiers in Arthritis

Frontiers in Arthritis

Volume: 1

Management of Osteoarthritis - A Holistic View

Indexed in: EBSCO.

Frontiers in Arthritis is an eBook series devoted to publishing the latest and the most important advances in arthritis research. Each volume brings together contributions from rheumatologists ad ...
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Role of Cartilage Regeneration in the Management of Early Knee Arthritis: Current Concepts

Pp. 70-90 (21)

Mark F. Sommerfeldt, Avijit Sharma and David C. Flanigan


In this chapter, we discuss review cartilage restoration surgery in the setting of early knee osteoarthritis (OA). We introduce an algorithmic approach to determining treatment and discuss procedures including microfracture, autologous matrix-induced chondrogenesis (AMIC®), osteochondral autograft transfer (OATS), osteochondral allografting (OCA), autologous chondrocyte implantation (ACI)/matrixassisted chondrocyte implantation (MACI), and stem cell therapy. These techniques have particular advantages and disadvantages. The authors share their approach and outline the protocol for postoperative rehabilitation.


ACI, AMIC, Cartilage, MACI, Microfracture, OATS, OCA, Osteoarthritis, Rehabilitation, Stem cell therapy.


OSU Sports Medicine and Cartilage Restoration Program, Department of Orthopaedics, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.