Use of Human Amnion/Chorion Allografts in the Treatment of Osteoarthritis
Pp. 59-69 (11)
Lauren A. Foy, Daniel L. Murphy and Ashish Anand
Currently, there is no cure for osteoarthritis (OA). Preliminary treatments
focus on symptomatic relief. Initially, patients receive cortisone shots, followed by
viscosupplementation in a few weeks. Platelet rich plasma injections are also an option.
Surgical options include debridement of joints, osteotomy, arthroscopy, or fusion of the
bones. Laboratory studies using rats support the use of amniotic membrane (AM) and
chorion membrane (CM) in the regeneration and repair of soft tissues. The potential for
CM and AM to moderate osteoarthritis has not been explored in length as yet; however,
indirect evidence suggests that they may have advantageous effects on cartilages.
Amnion, Arthritis, Chorion, DHACM, Growth factors, Knee,
Mesenchymal cells, Placenta, regenerative, Osteoarthritis.
GV Montgomery VA Medical Center, Jackson, Mississippi USA and Assistant Prof(Adj) Department of Orthopedic Surgery, University of Mississippi Medical Center, Jackson, Mississippi, USA.