Background: Contemporary neurobiology, periodontal medicine, and immunology are now
focusing on the relationship between chronic periodontitis and systemic diseases, which also include
Alzheimer’s disease (AD). However a causative relationship between dementia and periodontitis has yet
to be confirmed.
Objective: The aim of the study was to determine whether periodontal health status and cognitive abilities
are correlated with the relative changes in systemic measures of pro- and anti-inflammatory cytokines
as a reflection of systemic inflammation. We hypothesized that poor periodontal health status may
be associated with cognitive impairment and dementia via
the exacerbation of systemic inflammation.
Methods: Based on the periodontal and psychiatric examinations and the cytokine levels produced by
unstimulated and LPS-stimulated PBL isolated from 128 participants, we have examined if the coexisting
of these two clinically described conditions may have influence on the systemic inflammation. Mini-
Mental State Examination (MMSE) and Bleeding on Probing (BoP) test results were combined into the
one mathematical function U
, which determines the severity of specific condition, called Cognitive and
periodontal impairment state
. Similarly, the levels of cytokines were combined into the one mathematical
function V, whose value determines the level of Inflammatory state
. The correlation between U
Results: These results confirm that the presence of cognitive decline and the additional source of proinflammatory
mediators, like periodontal health problems, aggravate the systemic inflammation.
Conclusion: It is most likely that the comorbidity of these two disorders may deepen the cognitive impairment,
and neurodegenerative lesions and advance to dementia and AD.