Current Immunology Reviews

Cecil Czerkinsky  
Institut de Pharmacologie Moleculaire et Cellulaire
UMR 7275 CNRS-INSERM-UNISA
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Valbonne, 06560
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Versatile Functions of Heat Shock Factors: It is Not All About Stress

(E-pub Ahead of Print)

Author(s): Marek Andrzej Budzyński, Lea Sistonen.

Abstract:

Organisms are constantly exposed to acute and chronic stress conditions, which challenge the maintenance of protein homeostasis. Heat ShockProteins (HSPs) function as molecular chaperones to stabilize protein structures, facilitate refolding of misfolded proteins, and prevent uncontrolled protein aggregation. Therefore, HSPs serve as the first and last line ofdefense in the events of proteotoxic stresses. The stress-inducible expression of HSPs, which is a hallmark of the heat shock response, is understrict control of evolutionary conserved transcription factors, known as Heat Shock Factors (HSFs). Invertebrates have only a single HSF, whereas the HSF family in vertebrates consists of multiple members. Direct interactions of HSFs with various proteins, including HSPs, chromatin-associated proteins, and other HSF family members as well as their complex post-translational modifications, allow these transcription factors to function not only in stress responses but also in many other biological processes. For example, mammalian HSF1, HSF2 and HSF4 are fundamental for normal organismal development and healthy aging. Moreover, recent discoveries have highlighted the importance of HSFs in tumorigenesis, neurodegeneration, and metabolic disorders, which positions them as promising therapeutic targets in multiple human diseases. In this review, we focus on recent advances in the HSF biology and discuss the functional impact of HSFs on stress responses, development, aging, and age-related pathologies.

Keywords: aging, cancer, development, HSF, post-translational modification, protein homeostasis, transcription, stress response

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Article Details

VOLUME: 13
Year: 2017
(E-pub Ahead of Print)
DOI: 10.2174/1573395513666170316110147
Price: $95