Background: Due to the good biocompatibility, biodegradability, facile surface functionalization
and high water solubility, Bovine serum albumin has gain increasing attention in the nanomedicine.
Objective: Despite there are many reviews on albumin based nanoparticles, most of them focus on one
aspect of the albumin functionality, e.g., drug delivery, cancer theranostics or half-life extension in
vivo. This review aims to comprehensively summary bovine serum albumin as a versatile platform in
the applications of cancer imaging and therapy.
Methods: We review the extensive applications of bovine serum albumin in drug carrier, surface engineering
and biomimetic synthesis for cancer imaging and therapy.
Conclusion: Based on the studies reviewed, variety of in vitro and in vivo studies show good performance
of bovine serum albumin as the drug carrier, surface modification agent and biomimetic template
in cancer imaging and therapy. Nevertheless, there are still some issues to be solved, e.g., the technological
parameters for enhancing the drug loading efficiency and controlling drug release, optimizing
surface modification process to provide more stable nanoagents, investigation of the biomimetic
mechanism, in-depth study of their toxicity, further exploring their bioapplications, etc.