Background: Hyptis pectinata (Lamiaceae) is commonly known as ‘sambacaita' and
‘canudinho' in Brazil. In folk medicine, this plant is used to treat rhinopharyngitis, nasal congestion,
certain skin diseases, gastric disorders, fever and bacterial infections. The present study aimed
to study the phytoconstituents from the H. pectinata essential oil.
Methods: The chemical composition of the essential oil from the leaves of H. pectinata was determined
by GC-MS, the major component which was isolated and characterized by spectroscopic
methods (NMR 1D/2D and IR). Thermoanalytical techniques (TG/DTG and DSC) were used to
verify the thermal properties of calamusenone.
Results: In GC-MS results, 25 compounds were identified. The essential oil contained mainly sesquiterpenes
(92.09%), with calamusenone (62.61%). The potential of calamusenone for scavenging
peroxyl radicals, quench hydroxyl radicals, and superoxide anions and reducing the formation of
nitric oxide radicles indicates that this compound shows antioxidant capacity according to assay and
the tested concentration.
Conclusion: Together, the results conclude that the identified compounds could contribute to treat
various ailments and diseases induced by oxidative stress.