Objective: To explore the function of p42.3 in gastric carcinoma.
Methods: We summarized the intricate regulation of p42.3 in gastric carcinoma from several
aspects, namely, the structure features, the expression level, its regulation on cell cycle and EMT,
its relationship with miR-29a as well as the optimal feedback circuit involved in.
Results: We addressed the complex functions of p42.3 in regulating EMT, migration, invasion,
proliferation and the optimal regulation network in GC, as well as the significant up/down-stream
signal molecules involved in the pathway. We have also illuminated that miR-29a can inhibit cell
proliferation and block the cell cycle, at least in part, via the repression of p42.3.
Conclusion: In short, p42.3 might serve as a potential therapeutic target in the treatment of GC.